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The Xoloitzcuintle (), or Xolo, also known as the Mexican hairless dog, is one of several breeds of hairless dog. It is found in toy, miniature, and standard sizes. The Xolo also comes in a coated variety and coated and hairless can be born in the same litter. It is characterized by its lack of hair, wrinkles, and dental abnormalities. In Nahuatl, from which its name originates, its name is xōlōitzcuintli [ʃoːloːit͡sˈkʷint͡ɬi] (singular) and xōlōitzcuintin [ʃoːloːit͡sˈkʷintin] (plural). The name comes from the god Xolotl and itzcuīntli [it͡skʷiːnt͡ɬi], meaning dog in Nahuatl.==Linkage A 1999 genetic study using mitochondrial DNA found that the DNA sequences of the Xoloitzcuintle were identical to those of dogs from the Old World, and did not support a New World domestication for this breed. This early study did not find a close genetic relationship between Xoloitzcuintle and the Chinese Crested Dog, another hairless breed that is cited by the American Kennel Club as an ancestor to the Xoloitzcuintle.In 2018, an analysis of DNA from the entire genome indicated that domesticated dogs entered North America from Siberia 4,500 years after the first humans did, were isolated for the next 9,000 years. After contact with Europeans, these lineages were replaced by Eurasian dogs and their local descendants, like the Xoloitzcuintle. The pre-contact dogs exhibited a unique genetic signature that is now almost entirely gone.Their phenotype is a consequence of Canine Ectodermal Dysplasia caused by a mutation on the Foxl3 autosomal gene.

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xiphydriidae, xiraxara, xmas, xoana, xoanon, xosa, xurel, xyla, xylan, xylaria

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